Mental Health conditions including depression, anxiety and stress affect a sizeable proportion of university students. Yet little is known regarding the incidence of mental health issues among Indian University students. These mental health issues are generally caused by range of factors, including academic demands peer pressure and professional considerations One of the most important mental health problems impacting a large population across India and among the world is depression, leading to physical disease sucidial thoughts and among other negative outcomes. The objectives of this study were to understand and add to the body of knowledge on the role of mindfulness concerning depression , anxiety and stress among university students. The study revealved that depression and experimental avoidance are all strongly and negatively connected. Mindfulness had a considerable impact on the mediator.